Monday, October 24, 2016

Tylenol w/Codeine


Generic Name: acetaminophen and codeine (Oral route)


a-seet-a-MIN-oh-fen, KOE-deen FOS-fate


Oral route(Tablet)

Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 mg/day, and often involve more than one acetaminophen-containing product .



Commonly used brand name(s)

In the U.S.


  • APAP w/Codeine

  • Capital w/Codeine

  • Pyregesic-C

  • Tylenol w/Codeine

  • Tylenol w/Codeine #3

  • Tylenol w/Codeine #4

  • Tylenol with Codeine No. 3

  • Vopac

Available Dosage Forms:


  • Tablet

  • Capsule

  • Elixir

  • Suspension

  • Solution

Therapeutic Class: Opioid/Acetaminophen Combination


Chemical Class: Codeine


Uses For Tylenol w/Codeine


Acetaminophen and codeine oral suspension is used to relieve mild to moderate pain. The oral tablets are used to relieve mild to moderately severe pain.


Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.


Codeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.


When codeine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.


This medicine is available only with your doctor's prescription.


Before Using Tylenol w/Codeine


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of acetaminophen and codeine oral suspension in children younger than 3 years of age. Safety and efficacy have not been established.


No information is available on the relationship of age to the effects of acetaminophen and codeine tablets in the pediatric population. Safety and efficacy have not been established.


Geriatric


No information is available on the relationship of age to the effects of acetaminophen and codeine combination in geriatric patients.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.


  • Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Adinazolam

  • Alfentanil

  • Alprazolam

  • Amobarbital

  • Anileridine

  • Aprobarbital

  • Bromazepam

  • Brotizolam

  • Buprenorphine

  • Butabarbital

  • Butalbital

  • Butorphanol

  • Carisoprodol

  • Chloral Hydrate

  • Chlordiazepoxide

  • Chlorzoxazone

  • Clobazam

  • Clonazepam

  • Clorazepate

  • Codeine

  • Dantrolene

  • Dezocine

  • Diazepam

  • Estazolam

  • Ethchlorvynol

  • Fentanyl

  • Flunitrazepam

  • Flurazepam

  • Halazepam

  • Hydrocodone

  • Hydromorphone

  • Ketazolam

  • Levorphanol

  • Lorazepam

  • Lormetazepam

  • Medazepam

  • Meperidine

  • Mephenesin

  • Mephobarbital

  • Meprobamate

  • Metaxalone

  • Methocarbamol

  • Methohexital

  • Midazolam

  • Morphine

  • Morphine Sulfate Liposome

  • Nalbuphine

  • Nitrazepam

  • Nordazepam

  • Opium

  • Oxazepam

  • Oxycodone

  • Oxymorphone

  • Pentazocine

  • Pentobarbital

  • Phenobarbital

  • Prazepam

  • Propoxyphene

  • Quazepam

  • Remifentanil

  • Secobarbital

  • Sodium Oxybate

  • Sufentanil

  • Tapentadol

  • Temazepam

  • Thiopental

  • Triazolam

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acenocoumarol

  • Carbamazepine

  • Isoniazid

  • Phenytoin

  • Warfarin

  • Zidovudine

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.


  • Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.


  • Cabbage

  • Ethanol

Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Addison's disease (adrenal gland problem) or

  • Alcohol abuse, history of or

  • Breathing problems (e.g., chronic obstructive pulmonary disease [COPD], cor pulmonale, hypoxia) or

  • CNS depression or

  • Drug dependence, especially narcotic abuse or dependence, or history of or

  • Enlarged prostate (BPH, prostatic hypertrophy) or

  • Hypothyroidism (an underactive thyroid) or

  • Problems with passing urine—Use with caution. May increase risk for more serious side effects.

  • Allergy to sulfites or

  • Asthma—Tylenol® with codeine tablets contains sodium metabisulfite, which can cause allergic reactions in patients with these conditions.

  • Brain tumor or

  • Head injuries or

  • Increased pressure in the head—Some of the side effects of codeine can cause serious problems in people who have these medical problems.

  • Kidney disease or

  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

  • Respiratory depression (hypoventilation or slow breathing)—Use with caution. May make this condition worse.

  • Stomach or digestion problems—This medicine may mask the diagnosis of these conditions.

Proper Use of acetaminophen and codeine

This section provides information on the proper use of a number of products that contain acetaminophen and codeine. It may not be specific to Tylenol w/Codeine. Please read with care.


Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose. Large amounts of acetaminophen may cause liver damage.


Shake the oral suspension well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.


This combination medicine contains acetaminophen (Tylenol®). Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (suspension):
    • For mild to moderate pain:
      • Adults—15 milliliters (mL) or 1 tablespoonful every 4 hours as needed.

      • Children 7 to 12 years of age—10 mL (2 teaspoonfuls) 3 or 4 times per day.

      • Children 3 to 6 years of age—5 mL (1 teaspoonful) 3 or 4 times per day.

      • Children younger than 3 years of age—Use and dose must be determined by your doctor.



  • For oral dosage form (tablets):
    • For mild to moderately severe pain:
      • Adults—15 to 60 milligrams (mg) of codeine and 300 to 1000 mg of acetaminophen every 4 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 360 mg of codeine and 4000 mg of acetaminophen per 24 hours.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Tylenol w/Codeine


It is very important that your doctor check the progress of you or your child while you are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it.


It is against the law and dangerous for anyone else to use your medicine. Keep your unused medicine in a safe and secure place. People who are addicted to drugs might want to steal this medicine.


This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Also, there may be a greater risk of liver damage if you drink three or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.


This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose.


Check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.


This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop using this medicine and call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.


This medicine may make you dizzy, drowsy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.


Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.


For patients taking a codeine-containing medicine or any other narcotic analgesics (e.g., dihydrocodeine, hydrocodone, oxycodone, and pentazocine):


  • Contact your doctor right away if you have extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". Ultra-rapid metabolizers change codeine to morphine more quickly and completely than other people. As a result, there is too much morphine in the body and more side effects of morphine than usual.

Do not change your dose or suddenly stop using this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.


Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your child has the following symptoms: abnormal sleep pattern, diarrhea, high-pitched cry, irritability, shakiness or tremor, weight loss, vomiting, or failure to gain weight.


Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine. The results of certain tests may be affected by this medicine.


Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines, especially those containing acetaminophen (Tylenol (R)), and herbal or vitamin supplements.


Tylenol w/Codeine Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Difficult or troubled breathing

  • irregular, fast or slow, or shallow breathing

  • pale or blue lips, fingernails, or skin

  • shortness of breath

Incidence not known
  • Black, tarry stools

  • bleeding gums

  • blood in the urine or stools

  • cough or hoarseness

  • difficulty with swallowing

  • dizziness

  • fast heartbeat

  • fever with or without chills

  • general feeling of tiredness or weakness

  • hives

  • itching

  • lower back or side pain

  • painful or difficult urination

  • pinpoint red spots on the skin

  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

  • skin rash

  • sore throat

  • sores, ulcers, or white spots on the lips or in the mouth

  • tightness in the chest

  • unusual bleeding or bruising

  • unusual tiredness or weakness

  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Abdominal or stomach pain

  • bloody or cloudy urine

  • chills

  • constricted, pinpoint, or small pupils (black part of the eye)

  • convulsion

  • dark urine

  • headache

  • increased sweating

  • light-colored stools

  • loss of appetite

  • loss of consciousness

  • nausea

  • sudden decrease in the amount of urine

  • unpleasant breath odor

  • vomiting

  • vomiting of blood

  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Drowsiness

  • lightheadedness

  • relaxed and calm

  • sleepiness

Incidence not known
  • Difficulty having a bowel movement (stool)

  • false or unusual sense of well-being

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Tylenol w/Codeine side effects (in more detail)



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Tylenol Cold Head Congestion


Pronunciation: a-SEET-a-MIN-oh-fen/DEX-troe-meth-OR-fan/gwye-FEN-e-sin /FEN-il-EF-rin
Generic Name: Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine
Brand Name: Examples include Tylenol Cold Head Congestion and Tylenol Cold Multi Symptom


Tylenol Cold Head Congestion is used for:

Relieving pain, congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.


Tylenol Cold Head Congestion is an analgesic, decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, loosening mucus and lung secretions in the chest, and making coughs more productive. The analgesic and cough suppressant works in the brain to decrease pain and to help decrease the cough reflex to reduce a dry cough.


Do NOT use Tylenol Cold Head Congestion if:


  • you are allergic to any ingredient in Tylenol Cold Head Congestion

  • you have severe high blood pressure, rapid heartbeat, severe heart blood vessel disease, or other severe heart problems

  • you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Tylenol Cold Head Congestion:


Some medical conditions may interact with Tylenol Cold Head Congestion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of glaucoma, an enlarged prostate or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, an overactive thyroid, seizures, stroke, liver problems, or severe kidney problems, or if you drink 3 or more drinks with alcohol per day

  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

  • if you smoke or have a history of addiction to alcohol

Some MEDICINES MAY INTERACT with Tylenol Cold Head Congestion. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of Tylenol Cold Head Congestion's side effects may be increased

  • Anticoagulants (eg, warfarin), digoxin, or droxidopa because the risk of side effects such as bleeding, irregular heartbeat, or heart attack may be increased

  • Bromocriptine because the risk of its side effects may be increased by Tylenol Cold Head Congestion

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Tylenol Cold Head Congestion

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tylenol Cold Head Congestion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Tylenol Cold Head Congestion:


Use Tylenol Cold Head Congestion as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Tylenol Cold Head Congestion may be taken with or without food.

  • Drink plenty of water while taking Tylenol Cold Head Congestion.

  • If you miss a dose of Tylenol Cold Head Congestion, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tylenol Cold Head Congestion.



Important safety information:


  • Tylenol Cold Head Congestion may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tylenol Cold Head Congestion with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not take appetite suppressants while you use Tylenol Cold Head Congestion unless your doctor tells you to.

  • Tylenol Cold Head Congestion contains acetaminophen, dextromethorphan, guaifenesin, and phenylephrine. Before you start any new medicine, check the label to see if it has any of these medicines in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 7 days or if they get worse, check with your doctor.

  • Tylenol Cold Head Congestion may harm your liver. Your risk may be greater if you drink alcohol while you are using Tylenol Cold Head Congestion. Talk to your doctor before you take Tylenol Cold Head Congestion or other fever reducers if you drink more than 3 drinks with alcohol per day.

  • Tylenol Cold Head Congestion may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Tylenol Cold Head Congestion.

  • Tell your doctor or dentist that you take Tylenol Cold Head Congestion before you receive any medical or dental care, emergency care, or surgery.

  • Use Tylenol Cold Head Congestion with caution in the ELDERLY; they may be more sensitive to its effects.

  • Caution is advised when using Tylenol Cold Head Congestion in CHILDREN; they may be more sensitive to its effects.

  • Different brands of Tylenol Cold Head Congestion may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

  • PREGNANCY and BREAST-FEEDING: It is not known if Tylenol Cold Head Congestion can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tylenol Cold Head Congestion while you are pregnant. It is not known if Tylenol Cold Head Congestion is found in breast milk. Do not breast-feed while taking Tylenol Cold Head Congestion.


Possible side effects of Tylenol Cold Head Congestion:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; yellowing of skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Tylenol Cold Head Congestion side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; stomach pain; unusually fast, slow, or irregular heartbeat; vomiting; yellowing of skin or eyes.


Proper storage of Tylenol Cold Head Congestion:

Store Tylenol Cold Head Congestion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tylenol Cold Head Congestion out of the reach of children and away from pets.


General information:


  • If you have any questions about Tylenol Cold Head Congestion, please talk with your doctor, pharmacist, or other health care provider.

  • Tylenol Cold Head Congestion is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tylenol Cold Head Congestion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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Tylenol Cold


Pronunciation: a-seet-a-MIN-oh-fen/dex-troe-meth-OR-fan/gwye-FEN-e-sin /sue-doe-eh-FED-rin
Generic Name: Acetaminophen/Dextromethorphan/Guaifenesin/Pseudoephedrine
Brand Name: Examples include Duraflu and Tylenol Cold


Tylenol Cold is used for:

Relieving pain, congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.


Tylenol Cold is an analgesic, decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, loosening mucus and lung secretions in the chest, and making coughs more productive. The analgesic and cough suppressant works in the brain to decrease pain and to help decrease the cough reflex to reduce a dry cough.


Do NOT use Tylenol Cold if:


  • you are allergic to any ingredient in Tylenol Cold

  • you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)

  • you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Tylenol Cold:


Some medical conditions may interact with Tylenol Cold. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, plan to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of glaucoma, an enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, an overactive thyroid, seizures, stroke, or liver problems, or if you consume more than 3 alcohol-containing drinks per day

  • if you have a chronic cough, lung problems (eg, asthma, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Tylenol Cold. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects from Tylenol Cold may be increased

  • Anticoagulants (eg, warfarin), digoxin, or droxidopa because the risk of side effects such as bleeding, irregular heartbeat or heart attack may be increased

  • Bromocriptine because the risk of side effects may be increased by Tylenol Cold

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by Tylenol Cold

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tylenol Cold may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Tylenol Cold:


Use Tylenol Cold as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Tylenol Cold may be taken with or without food.

  • Drink plenty of water while taking Tylenol Cold.

  • If you miss a dose of Tylenol Cold, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tylenol Cold.



Important safety information:


  • Tylenol Cold may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Tylenol Cold. Using Tylenol Cold alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • Do not take appetite suppressants while you are taking Tylenol Cold without checking with your doctor.

  • Tylenol Cold contains acetaminophen and pseudoephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen or pseudoephedrine. If it does or if you are uncertain, contact your doctor or pharmacist.

  • Do NOT exceed the recommended dose or take Tylenol Cold for longer than prescribed without checking with your doctor.

  • If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.

  • Tylenol Cold may cause liver damage. If you consume 3 or more alcohol-containing drinks every day, ask your doctor if you should take Tylenol Cold or other pain relievers/fever reducers. Alcohol use combined with Tylenol Cold may increase your risk for liver damage.

  • Tylenol Cold may interfere with certain lab test results. Make sure that all of your doctors and laboratory personnel know that you are taking Tylenol Cold.

  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Tylenol Cold.

  • Use Tylenol Cold with caution in the ELDERLY because they may be more sensitive to its effects.

  • Caution is advised when using Tylenol Cold in CHILDREN because they may be more sensitive to its effects.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Tylenol Cold, discuss with your doctor the benefits and risks of using Tylenol Cold during pregnancy. It is unknown if Tylenol Cold is excreted in breast milk. Do not breast-feed while taking Tylenol Cold.


Possible side effects of Tylenol Cold:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; yellowing of skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.



If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; stomach pain; unusually fast, slow, or irregular heartbeat; vomiting; yellowing of skin or eyes.


Proper storage of Tylenol Cold:

Store Tylenol Cold at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tylenol Cold out of the reach of children and away from pets.


General information:


  • If you have any questions about Tylenol Cold, please talk with your doctor, pharmacist, or other health care provider.

  • Tylenol Cold is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tylenol Cold. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tylenol Cold resources


  • Tylenol Cold Use in Pregnancy & Breastfeeding
  • Tylenol Cold Drug Interactions
  • 0 Reviews for Tylenol Cold - Add your own review/rating


Compare Tylenol Cold with other medications


  • Cold Symptoms
  • Cough and Nasal Congestion

Typhim Vi


Generic Name: typhoid vi polysaccharide vaccine (Intramuscular route)


TYE-foid Vi pol-ee-SAK-a-ride VAX-een


Commonly used brand name(s)

In the U.S.


  • Typhim Vi

  • Typhoid Vi Polysaccharide Vaccine

Available Dosage Forms:


  • Solution

  • Injectable

Therapeutic Class: Vaccine


Uses For Typhim Vi


Typhoid fever is a serious disease that can cause death. It is caused by a germ called Salmonella typhi, and is spread most often through infected food or water. Typhoid may also be spread by close person-to-person contact with infected persons (such as occurs with persons living in the same household). Some infected persons do not appear to be sick, but they can still spread the germ to others.


Typhoid fever is very rare in the U.S. and other areas of the world that have good water and sewage (waste) systems. However, it is a problem in parts of the world that do not have such systems. If you are traveling to certain countries or remote, out-of-the-way areas, typhoid vaccine will help protect you from typhoid fever. The U.S. Centers for Disease Control (CDC) currently recommend caution in the following areas of the world:


  • Africa

  • Asia

  • Latin America

Typhoid vaccine given by injection helps prevent typhoid fever, but does not provide 100% protection. Therefore, it is very important to avoid infected persons and food and water that may be infected, even if you have received the vaccine.


To get the best possible protection against typhoid, you should receive the vaccine at least 1 week before you travel to areas where you may be exposed to typhoid.


If you will be traveling regularly to parts of the world where typhoid is a problem, you should get a booster (repeat) dose of the vaccine every 2 years.


Typhoid vaccine is to be used only by or under the supervision of a doctor.


Before Using Typhim Vi


In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Typhoid Vi polysaccharide vaccine is not recommended for infants and children younger than 2 years of age. For children 2 years of age and over, this vaccine is not expected to cause different side effects or problems than it does in adults.


Geriatric


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of typhoid vaccine in the elderly with use in other age groups, this vaccine is not expected to cause different side effects or problems in older people than it does in younger adults.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Tacrolimus

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Previous sensitivity reaction to typhoid vaccine—Use of typhoid vaccine is not recommended

  • Severe illness with fever—The symptoms of the condition may be confused with the side effects of the vaccine

Proper Use of Typhim Vi


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


The dose of typhoid Vi polysaccharide vaccine is the same for all patients 2 years of age and older. For infants and children up to two years of age, the use of typhoid Vi polysaccharide vaccine is not recommended.


  • For injection dosage form:
    • For prevention of typhoid fever:
      • Adults and children 2 years of age and older—One dose injected into a muscle.

      • Children up to 2 years of age—Use is not recommended.



Typhim Vi Side Effects


Along with its needed effects, a vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. It is very important that you tell your doctor about any side effects that occur after a dose of typhoid vaccine, even though the side effect may have gone away without treatment. Some types of side effects may mean that you should not receive any more doses of typhoid vaccine.


Check with your doctor immediately if any of the following side effects occur:


Rare
  • Difficulty in breathing or swallowing

  • hives

  • itching, especially of feet or hands

  • reddening of skin, especially around ears

  • swelling of eyes, face, or inside of nose

  • unusual tiredness or weakness (sudden and severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Fever

  • general feeling of discomfort or illness

  • headache

  • muscle pain

  • pain, redness, or swelling at place of injection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Typhim Vi side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Typhim Vi resources


  • Typhim Vi Side Effects (in more detail)
  • Typhim Vi Use in Pregnancy & Breastfeeding
  • Typhim Vi Drug Interactions
  • Typhim Vi Support Group
  • 0 Reviews for Typhim Vi - Add your own review/rating


  • Typhim Vi MedFacts Consumer Leaflet (Wolters Kluwer)

  • Typhim VI Concise Consumer Information (Cerner Multum)

  • Typhoid Vaccine Monograph (AHFS DI)



Compare Typhim Vi with other medications


  • Typhoid Prophylaxis

Tylenol PM


Generic Name: acetaminophen and diphenhydramine (a SEET a MIN oh fen and DYE fen HYE dra meen)

Brand Names: Anacin P.M. Aspirin Free, Coricidin Night Time Cold Relief, Excedrin PM, Excedrin PM Caplet, Excedrin PM Express Gels, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Percogesic Extra Strength, Percogesic Original Strength, Tylenol Cold Relief Caplet, Tylenol Cold Relief Nighttime, Tylenol Cold Relief Nighttime Caplet, Tylenol Extra Strength PM, Tylenol Extra Strength PM Rapid Release Gelcaps, Tylenol Extra Strength PM Vanilla Caplet, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom with Pain Relief


What is Tylenol PM (acetaminophen and diphenhydramine)?

Acetaminophen is a pain reliever and fever reducer.


Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


The combination of acetaminophen and diphenhydramine is used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.


Acetaminophen and diphenhydramine may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Tylenol PM (acetaminophen and diphenhydramine)?


Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, heart disease, or overactive thyroid. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen and can increase certain side effects of diphenhydramine. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.

What should I discuss with my healthcare provider before taking Tylenol PM (acetaminophen and diphenhydramine)?


You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:



  • liver disease, cirrhosis, or a history of alcoholism;




  • a blockage in your digestive tract (stomach or intestines);




  • kidney disease;




  • cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;




  • enlarged prostate or urination problems;




  • low blood pressure; or




  • if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).




It is not known whether acetaminophen and diphenhydramine will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant. This medication may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use this medicine without your doctor's advice if you are breast-feeding a baby.

How should I take Tylenol PM (acetaminophen and diphenhydramine)?


Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.


Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.


Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.


If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?


Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1 800 222 1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.


Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.


What should I avoid while taking Tylenol PM (acetaminophen and diphenhydramine)?


Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen, and can increase certain side effects of diphenhydramine. This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Tylenol PM (acetaminophen and diphenhydramine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • chest pain, rapid pulse, fast or uneven heart rate;




  • confusion, hallucinations, severe nervousness;




  • tremor, seizure (convulsions);




  • easy bruising or bleeding, unusual weakness;




  • urinating less than usual or not at all; or




  • nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes).



Less serious side effects may include:



  • dizziness, drowsiness;




  • mild headache;




  • dry mouth, nose, or throat;




  • constipation;




  • blurred vision;




  • feeling nervous; or




  • sleep problems (insomnia);



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Tylenol PM (acetaminophen and diphenhydramine)?


Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by diphenhydramine.

Tell your doctor about all other medicines you use, especially:



  • leflunomide (Arava);




  • topiramate (Topamax);




  • zonisamide (Zonegran);




  • diphenhydramine (Benadryl) applied to the skin;




  • an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;




  • an antidepressant;




  • birth control pills or hormone replacement therapy;




  • bladder or urinary medications;




  • blood pressure medication;




  • a bronchodilator;




  • cancer medicine;




  • cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;




  • gout or arthritis medications (including gold injections);




  • HIV/AIDS medication;




  • medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;




  • medicines to treat psychiatric disorders;




  • an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or




  • seizure medication.



This list is not complete and other drugs may interact with acetaminophen and diphenhydramine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Tylenol PM resources


  • Tylenol PM Side Effects (in more detail)
  • Tylenol PM Use in Pregnancy & Breastfeeding
  • Drug Images
  • Tylenol PM Drug Interactions
  • Tylenol PM Support Group
  • 6 Reviews for Tylenol PM - Add your own review/rating


Compare Tylenol PM with other medications


  • Headache
  • Insomnia
  • Pain


Where can I get more information?


  • Your pharmacist can provide more information about acetaminophen and diphenhydramine.

See also: Tylenol PM side effects (in more detail)


Tylenol Cold Multi-Symptom Liquid


Pronunciation: a-SEET-a-MIN-oh-fen/dox-IL-a-meen/DEX-troe-meth-OR-fan/FEN-il-EF-rin
Generic Name: Acetaminophen/Doxylamine/Dextromethorphan/Phenylephrine
Brand Name: Tylenol Cold Multi-Symptom


Tylenol Cold Multi-Symptom Liquid is used for:

Relieving symptoms of fever, headache, pain, sinus congestion, runny nose, sneezing, sore throat, and cough due to colds, flu, upper respiratory infections, and allergies. It may also used for other conditions as determined by your doctor.


Tylenol Cold Multi-Symptom Liquid is an analgesic, antihistamine, cough suppressant, and decongestant combination. The analgesic works in the brain to decrease pain and reduce fever. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes, runny nose, and sneezing. The cough suppressant works in the brain to reduce a dry or unproductive cough. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages, which helps relieve nasal congestion and pain associated with sinus pressure.


Do NOT use Tylenol Cold Multi-Symptom Liquid if:


  • you are allergic to any ingredient in Tylenol Cold Multi-Symptom Liquid

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you take droxidopa or sodium oxybate (GHB), or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Tylenol Cold Multi-Symptom Liquid:


Some medical conditions may interact with Tylenol Cold Multi-Symptom Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a fast, slow, or irregular heartbeat

  • if you have a history of liver or kidney problems; adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; blood vessel problems; stroke; glaucoma or increased pressure in the eye; a blockage of your bladder, stomach, or intestines; ulcers; trouble sleeping; trouble urinating; an enlarged prostate or other prostate problems; seizures; or thyroid problems

  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), sleep apnea, or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

  • if you smoke, have a history of addiction to alcohol, drink 3 or more drinks with alcohol per day, or are on a low-sodium diet

Some MEDICINES MAY INTERACT with Tylenol Cold Multi-Symptom Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Anticoagulants (eg, warfarin), digoxin, or droxidopa because risk of bleeding, irregular heartbeat, or heart attack may be increased

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAOIs (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) they may increase the risk of Tylenol Cold Multi-Symptom Liquid's side effects

  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Tylenol Cold Multi-Symptom Liquid

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Tylenol Cold Multi-Symptom Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tylenol Cold Multi-Symptom Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Tylenol Cold Multi-Symptom Liquid:


Use Tylenol Cold Multi-Symptom Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Tylenol Cold Multi-Symptom Liquid by mouth with or without food.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If you miss a dose of Tylenol Cold Multi-Symptom Liquid, take it as soon as you remember. Continue to take it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Tylenol Cold Multi-Symptom Liquid.



Important safety information:


  • Tylenol Cold Multi-Symptom Liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Tylenol Cold Multi-Symptom Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not drink alcohol while you are taking Tylenol Cold Multi-Symptom Liquid.

  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tylenol Cold Multi-Symptom Liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

  • Do not take diet or appetite control medicines while you use Tylenol Cold Multi-Symptom Liquid unless your doctor tells you otherwise.

  • Tylenol Cold Multi-Symptom Liquid has acetaminophen, dextromethorphan, doxylamine, and phenylephrine in it. Before you start any new medicine, check the label to see if it has acetaminophen, dextromethorphan, an antihistamine, or a decongestant in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do not use Tylenol Cold Multi-Symptom Liquid for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.

  • Do NOT take more than the recommended dose or take for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 7 days, if they get worse, or if they occur along with a persistent fever, check with your doctor.

  • Contact your doctor if you have a sore throat that is severe, lasts more than 2 days, or occurs with fever, rash, headache, nausea, or vomiting.

  • Contact your doctor if you have a fever that lasts for more than 3 days.

  • Contact your doctor if you have a cough that lasts more than 7 days, goes away and then comes back, or occurs along with persistent fever, rash, or headache.

  • Tylenol Cold Multi-Symptom Liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tylenol Cold Multi-Symptom Liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Tylenol Cold Multi-Symptom Liquid may harm your liver. Your risk may be greater if you drink alcohol while you are using Tylenol Cold Multi-Symptom Liquid. Talk to your doctor before you take Tylenol Cold Multi-Symptom Liquid or other fever reducers if you drink more than 3 drinks with alcohol per day.

  • Tylenol Cold Multi-Symptom Liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Tylenol Cold Multi-Symptom Liquid for a few days before the tests.

  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take Tylenol Cold Multi-Symptom Liquid.

  • Tell your doctor or dentist that you take Tylenol Cold Multi-Symptom Liquid before you receive any medical or dental care, emergency care, or surgery.

  • Use Tylenol Cold Multi-Symptom Liquid with caution in the ELDERLY; they may be more sensitive to its effects.

  • Caution is advised when using Tylenol Cold Multi-Symptom Liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.

  • Different brands of Tylenol Cold Multi-Symptom Liquid may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tylenol Cold Multi-Symptom Liquid while you are pregnant. Some of the ingredients in Tylenol Cold Multi-Symptom Liquid are found in breast milk. If you are or will be breast-feeding while you use Tylenol Cold Multi-Symptom Liquid, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Tylenol Cold Multi-Symptom Liquid:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mental or mood changes; pale stools; seizures; severe nervousness, drowsiness, or trouble sleeping; severe or persistent dizziness, lightheadedness, or headache; severe or persistent stomach pain, nausea, or vomiting; tremor; unusual fatigue; vision changes; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.



If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; fever; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremors; trouble breathing; unusual drowsiness or dizziness; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Tylenol Cold Multi-Symptom Liquid:

Store Tylenol Cold Multi-Symptom Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tylenol Cold Multi-Symptom Liquid out of the reach of children and away from pets.


General information:


  • If you have any questions about Tylenol Cold Multi-Symptom Liquid, please talk with your doctor, pharmacist, or other health care provider.

  • Tylenol Cold Multi-Symptom Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tylenol Cold Multi-Symptom Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tylenol Cold Multi-Symptom resources


  • Tylenol Cold Multi-Symptom Use in Pregnancy & Breastfeeding
  • Tylenol Cold Multi-Symptom Drug Interactions
  • Tylenol Cold Multi-Symptom Support Group
  • 0 Reviews for Tylenol Cold Multi-Symptom - Add your own review/rating


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  • Cold Symptoms
  • Cough
  • Cough and Nasal Congestion
  • Nasal Congestion
  • Pain/Fever
  • Rhinorrhea

typhoid vaccine, live


TYE-foid VAX-een, lyve


Commonly used brand name(s)

In the U.S.


  • Vivotif

Available Dosage Forms:


  • Capsule, Delayed Release

  • Capsule

Therapeutic Class: Vaccine


Uses For typhoid vaccine, live


Typhoid fever is a serious disease that can cause death. It is caused by a germ called Salmonella typhi, and is spread most often through infected food or water. Typhoid may also be spread by close person-to-person contact with infected persons (such as occurs with persons living in the same household). Some infected persons do not appear to be sick, but they can still spread the germ to others.


Typhoid fever is very rare in the United States (U.S.) and other areas of the world that have good water and sewage (waste) systems. However, it is a problem in parts of the world that do not have such systems. If you are traveling to certain countries or remote areas, typhoid vaccine will help protect you from typhoid fever. The U.S. CDC recommends caution in the following areas of the world:


  • Africa

  • Asia

  • Latin America

Typhoid vaccine taken by mouth helps prevent typhoid fever, but does not provide 100% protection. Therefore, it is very important to avoid infected persons and food and water that may be infected, even if you have taken the vaccine.


To get the best possible protection against typhoid, you should complete the vaccine dosing schedule (all 4 doses of the vaccine) at least 1 week before travel to areas where you may be exposed to typhoid.


If you will be traveling regularly to parts of the world where typhoid is a problem, you should get a booster (repeat) dose of the vaccine every 5 years.


Typhoid vaccine is available only from a health care professional.


Before Using typhoid vaccine, live


In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to typhoid vaccine, live or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Typhoid vaccine is not recommended for infants and children up to 6 years of age. Although there is no specific information comparing use of typhoid vaccine in children 6 years of age and over with use in other age groups, this vaccine is not expected to cause different side effects or problems in these children than it does in adults.


Geriatric


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of typhoid vaccine in the elderly with use in other age groups, this vaccine is not expected to cause different side effects or problems in older people than it does in younger adults.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Aclarubicin

  • Adalimumab

  • Aldesleukin

  • Altretamine

  • Amonafide

  • Amsacrine

  • Asparaginase

  • Azacitidine

  • Azathioprine

  • Bleomycin

  • Broxuridine

  • Busulfan

  • Capecitabine

  • Carboplatin

  • Carmustine

  • Certolizumab Pegol

  • Chlorambucil

  • Cisplatin

  • Cladribine

  • Cyclophosphamide

  • Cytarabine

  • Cytarabine Liposome

  • Dacarbazine

  • Dactinomycin

  • Daunorubicin

  • Daunorubicin Citrate Liposome

  • Decitabine

  • Docetaxel

  • Doxifluridine

  • Doxorubicin Hydrochloride

  • Doxorubicin Hydrochloride Liposome

  • Edatrexate

  • Eflornithine

  • Epirubicin

  • Estramustine

  • Etanercept

  • Etoposide

  • Everolimus

  • Fingolimod

  • Floxuridine

  • Fludarabine

  • Fluorouracil

  • Fotemustine

  • Gallium Nitrate

  • Gemcitabine

  • Golimumab

  • Hydroxyurea

  • Idarubicin

  • Ifosfamide

  • Irinotecan

  • Lomustine

  • Mechlorethamine

  • Melphalan

  • Mercaptopurine

  • Methotrexate

  • Mitolactol

  • Mitomycin

  • Mitotane

  • Mitoxantrone

  • Mycophenolic Acid

  • Oxaliplatin

  • Paclitaxel

  • Pegaspargase

  • Pentostatin

  • Pipobroman

  • Pirarubicin

  • Plicamycin

  • Procarbazine

  • Raltitrexed

  • Rilonacept

  • Rituximab

  • Sirolimus

  • Streptozocin

  • Tacrolimus

  • Teceleukin

  • Tegafur

  • Temsirolimus

  • Teniposide

  • Thioguanine

  • Thiotepa

  • Topotecan

  • Treosulfan

  • Trimetrexate

  • Trofosfamide

  • Uracil Mustard

  • Ustekinumab

  • Vinblastine

  • Vincristine

  • Vincristine Liposome

  • Vindesine

  • Vinorelbine

Receiving this vaccine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Abatacept

  • Cytomegalovirus Immune Globulin, Human

  • Leflunomide

  • Vaccinia Immune Globulin, Human

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Diarrhea or

  • Fever or

  • Other illness (severe) or

  • Stomach or intestinal illness (severe) or

  • Vomiting—These conditions may reduce the useful effect of the vaccine.

  • Immune deficiency condition, including HIV or AIDS—May increase the chance of side effects from the vaccine.

Proper Use of typhoid vaccine, live


It is important that all 4 doses of the vaccine be taken exactly as directed. If all the doses are not taken or if doses are not taken at the correct times, the vaccine may not work properly.


The vaccine capsules are meant to dissolve in the intestines. Therefore, they should be inspected to make sure that they are not broken or cracked when you take them. If any are broken or cracked, you will need to replace them.


Typhoid vaccine must be stored in the refrigerator at a temperature between 2 and 8 degrees C (35.6 and 46.4 degrees F) at all times. If the vaccine is left at room temperature, it will lose its effectiveness. Therefore, remember to replace unused vaccine in the refrigerator between doses.


Each dose of the vaccine should be taken approximately 1 hour before a meal. Take with a cold or lukewarm drink that has a temperature that does not exceed body temperature (eg, 37 degrees C or 98.6 degrees F).


Swallow the capsule whole. Do not chew it before swallowing. Also swallow the capsule as soon as possible after you place it in your mouth.


Dosing


The dose of typhoid vaccine, live will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of typhoid vaccine, live. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • Take 1 capsule by mouth every other day for a total of 4 doses.

Missed Dose


Call your doctor or pharmacist for instructions.


If you do not remember the missed dose until the next day, take the missed dose at that time and reschedule your every-other-day doses from then. It is important that this vaccine be taken exactly as directed so it can give you the most protection against typhoid fever.


Storage


Store in the refrigerator. Do not freeze.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using typhoid vaccine, live


Tell all of your doctors that you have taken this vaccine if you plan to receive any other live vaccines within 1 month after the last dose.


If you are receiving this vaccine, do not take proguanil (Paludrine(R)) as a single medicine (not available in the United States) for at least 10 days after your last dose.


typhoid vaccine, live Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


  • Difficulty with breathing or swallowing

  • hives

  • itching, especially of the feet or hands

  • reddening of the skin, especially around the ears

  • swelling of the eyes, face, or inside of the nose

  • unusual tiredness or weakness that is sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common or rare
  • Diarrhea

  • fever

  • nausea

  • skin rash

  • stomach cramps or pain

  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: typhoid vaccine, live side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More typhoid vaccine, live resources


  • Typhoid vaccine, live Side Effects (in more detail)
  • Typhoid vaccine, live Use in Pregnancy & Breastfeeding
  • Typhoid vaccine, live Drug Interactions
  • Typhoid vaccine, live Support Group
  • 0 Reviews for Typhoid vaccine, live - Add your own review/rating


  • Typhoid Vaccine Monograph (AHFS DI)

  • Vivotif Berna Concise Consumer Information (Cerner Multum)



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